The good thing about using Winstrol when compared to the majority of other anabolic steroids on the market today is that Winstrol is considered to be a mild supplement when it comes to side effects, which means that unless you are overusing and abusing Winstrol, the odds of you getting any of the side effects will be minimal at best. Another important thing to keep in mind is that like what was mentioned earlier about Winstrol being a gender friendly substance means that both the men and the women using this product can both experience the potential side effects. Winstrol is easily one of the greatest substances in the market today and it is widely used by just about all those looking to build that bodybuilder like body, but there are some side effects to take note of and if you use Winstrol correctly, the side effects are nothing but a thing of low concern.
Winstrol in particular is known for exhibiting some profound negative cholesterol changes in humans as evidenced by some clinical studies. Winstrol administered orally at just 6mg daily for a 6 week period resulted in a reduction of HDL by 33%, alongside an LDL increase of 29% (all test subjects were healthy males engaged in regular physical exercise)  . Even the injectable Winstrol preparation has demonstrated to produce negative cholesterol profile changes. Only a single 50mg dose of injectable Winstrol was administered to 12 healthy test subjects, and resulted in significant HDL reduction with an increase in LDL (these negative cholesterol changes remained for a 4 week period following administration before returning to normal values)  .
Trenbolone also has progestagenic affects. Tren, as we’ve previously said, possesses strong androgenic properties. Tren is not known in the anabolic steroid community to cause gyno. However, it would be interesting to observe many cycles of anabolic steroids which include a heavily aromatizing steroid with trenbolone. No doubt many athletes have combined tren and testosterone with miraculous results. It would be interesting to note amongst these individuals if they have ever developed gyno when combining the drugs, but not when taking them alone. Remember, progesterone sensitizes the body to estrogen, so whatever estrogen is available will be more likely to act out and cause the negative effects we know estrogen is responsible for. The moral of the story is to be cautious and knowledgeable about the drugs you are combining. Actually, that should be true whether you are 21 and raving at a night club on e, or a responsible individual, through with your party stage, and maximizing your safe use of anabolic steroids. Drug synergy can be an amazingly useful tool when used for maximal gain, but can be very unfortunate and even dangerous if multiple negative properties of drugs are allowed to gather inside the body. We will talk more about the specifics of drug synergy in another section.