Patients with acute cholecystitis should be admitted to the hospital for intravenous antibiotics. Cholecystectomy is usually performed within 24-48 hours. Patients who are poor operative candidates can be managed with antibiotics alone with success. However, in the presence of a palpable gallbladder or abnormal liver function tests nonoperative therapy usually fails. Persistence or worsening of fever or elevation in the white blood cell count despite antibiotic treatment are indications for immediate surgery. In most cases laparoscopic cholecystectomy will be successful. Conversion to open cholecystectomy is more likely in patients with acute cholecystitis.