The manufacturers of certain testosterone products (., AndroGel and Striant) state that their products are contraindicated in patients with soybean, soy, or soya lecithin hypersensitivity because they are derived partially from soy plants. There is a risk of serious hypersensitivity reactions or anaphylaxis with the use of testosterone undecanoate (Aveed) oil for injection. These allergic reactions can occur after any injection of testosterone undecanoate during the course of therapy, including after the first dose. Observe patients in the healthcare setting for 30 minutes after an Aveed injection in order to provide appropriate medical treatment in the event of serious hypersensitivity reactions or anaphylaxis. The Aveed injection contains benzyl benzoate, the ester of benzyl alcohol and benzoic acid, and refined castor oil. Therefore, testosterone undecanoate use is contraindicated in patients with polyoxyethylated castor oil hypersensitivity, benzoic acid hypersensitivity, or benzyl alcohol hypersensitivity. Patients with suspected hypersensitivity reactions should not be re-treated with testosterone undecanoate injection.
Testosterone, like many anabolic steroids, was classified as a controlled substance in 1991. Testosterone is administered parenterally in normal and delayed-release (depot) forms. In September 1995, the FDA approved testosterone transdermal patches (Androderm), and many transdermal forms and brands are now available including implants, gels, and topical solutions. A testosterone buccal system, Striant, was FDA-approved in July 2003; Striant is a mucoadhesive product that adheres to the buccal mucosa and provides a controlled and sustained release of testosterone. In May 2014, the FDA approved an intranasal gel formulation of testosterone (Natesto). A transdermal patch (Intrinsa) for hormone replacement in women is under investigation; the daily dosages used in women are much lower than for products used in males. The FDA refused approval for Intrinsa in 2004 stating that more data regarding safety, especially in relation to cardiovascular and breast health, were required.
However, when AndroGel use is stopped, testosterone levels will drop below normal in a matter of five days. Low testosterone levels might be a condition that won't go away but that doesn't mean you can't deal with it. Use your medication regularly, keep testosterone levels normal, and you will experience relief from your symptoms.
How to use androgel
When you're using AndroGel (transdermal testosterone), it is ideal that you apply it at the same time each day, preferably in the morning. While you can apply the gel on several sites on your body, like the upper arms and abdominal area (but never the penis, scrotum, or genitals), follow the dosage prescribed to you and just spread out each dose. After application, wash your hands thoroughly with water and soap and let the application sites dry and then cover up to prevent transfer. Don't forget to prime the pump before your first use to ensure accurate dosage. Just press the pump three times and then discard the gel. Take care to properly dispose of the gel so that it won't come in contact with other people.
AndroGel (transdermal testosterone) is not suitable for use by males below 18 years old. You should also avoid using it if you have prostate cancer, breast cancer, or any of the ingredients found in it. Increased risks for acquiring prostate cancer or enlarged prostates are also more prevalent in older men. Women cannot and must not use AndroGel due to potential virilizing effects. Skin contact must also be avoided, specially by pregnant women, since it can cause fetal harm, as well as those nursing since it may cause adverse reactions in nursing infants. Virilizing effects are also possible in fetuses and infants.
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