Fluid and electrolyte disturbances: Retention of sodium, chloride, water, potassium, calcium, and inorganic phosphates.
Gastrointestinal: Nausea, cholestatic jaundice, alterations in liver function tests, rarely hepatocellular neoplasms and peliosis hepatis (see WARNINGS ).
Hematologic: Suppression of clotting factors II, V, VII, and X, bleeding in patients on concomitant anticoagulant therapy, and polycythemia.
Nervous system: Increased or decreased libido, headache, anxiety, depression, and generalized paresthesia.
Allergic: Hypersensitivity, including skin manifestations and anaphylactoid reactions.
Vascular Disorders: venous thromboembolism
Miscellaneous: Inflammation and pain at the site of intramuscular injection.
The side effects of Androderm can include high blood pressure due to high levels of water retention. However, water retention is highly unlikely due to the low level dosing plans that will be prescribed and easily combatable with anti-estrogen medications if needed. The use of exogenous testosterone can also have a negative impact on cholesterol, particularly in the suppression or reduction of HDL cholesterol. However, therapeutic doses of testosterone to even moderate performance doses do not appear to have a strong, negative statistical impact on cholesterol when testosterone is used alone. When the use of an AI is conjoined with testosterone, this does appear to create a notable impact on HDL reductions. A negative impact cannot occur with the use of a SERM; in fact, SERM’s will actually improve cholesterol levels due to their estrogenic activity in the liver.
While cholesterol issues are possible, they are also easy to avoid. AI’s should not be used unless necessary, but even if necessary healthy cholesterol levels can be maintained with a healthy lifestyle. Limiting saturated fats and simple sugars is a good place to start along with plenty of omega fatty acids. Daily fish oil supplementation is recommended as is daily cardiovascular activity.